Comparing Diuretic Strategies in Hospitalized Heart Failure

• Status: Not yet recruiting
• Trial end date: 2022-06-01
• Target enrollment: 0
• Participant gender: All

Summary

We will conduct a pragmatic randomized trial comparing whether using a combination of two types of diuretics (loop + thiazide) compared with using a single diuretic (loop only) will result in shorter hospital stays for patients hospitalized with heart failure.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Stanford University
• Collaborator: American Heart Association
• Treatments: Diuretics; Sodium Chloride Symporter Inhibitors; Sodium Potassium Chloride Symporter Inhibitors

Criteria

Inclusion Criteria:

Any adult (age ≥18 years) admitted to the Heart Failure Service at Stanford Health Care with an indication for treatment with a diuretic.

Exclusion Criteria:

1. admission to the intensive care unit or cardiac care units

2. maintenance dialysis on admission

3. any mechanical circulatory support on admission

4. history of heart transplant

5. allergy / intolerance to loop or thiazide diuretics

6. admission serum sodium < 125 meq/L (from EPIC)

7. admission serum potassium < 3.0 meq/L (from EPIC)