Comparing Cefepime Versus Cefazolin Plus Ceftazidime for CAPD-associated Peritonitis

• Status: Completed
• Trial end date: 2016-11-30
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to compare the efficacy of empirical antibiotics of CAPD-associated peritonitis with intraperitoneal, continuous dosing of cefepime monotherapy versus combination of cefazolin and ceftazidime. Patients were randomized to be administered either intraperitoneal cefepime 1 g loading then 250 mg all exchanges (treatment group) or cefazolin and ceftazidime (control group) in the same dose.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chulalongkorn University
• Collaborators: Siam Pharmaceutical Co Ltd; The Kidney Foundation of Thailand
• Treatments: Cefazolin; Cefepime; Ceftazidime; Cephalosporins

Criteria

Inclusion Criteria:

• Age more than 18 years

• CAPD initiation more than 4 weeks

Exclusion Criteria:

• Exit site or tunnel infection

• Sepsis

• Previous CAPD-associated peritonitis treatment within 4 weeks

• Drug allergy to cephalosporin

• Tenckhoff catheter malfunction

• Hospitalization more than 48 hours

• Fungal or Mycobacterium infection

• Suspected secondary peritonitis

• Concomitant antibiotics.