Comparing Anesthetic Techniques in Children Having Esophagogastroduodenoscopies

• Status: Completed
• Trial end date: 2013-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this research study is to compare the safety and effectiveness of three commonly used techniques for delivering anesthesia during a procedure known as esophagogastroduodenoscopy.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Children's Hospital Medical Center, Cincinnati
• Treatments: Anesthetics; Ondansetron; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• Patient presenting as out-patients, scheduled to receive an anesthetic for a diagnostic EGD

• Patient must be a candidate for any of the three anesthetic techniques. This decision will be made by a staff member of the Department of Anesthesiology, who is not a member of the study team and will be responsible for obtaining consent for anesthesia

• Patient must be between ages 1 and 12 years (inclusive)

• Patient must be American Society of Anesthesiology (ASA) class I or II;

• Eosinophilic esophagitis (EE) patients classified as an ASA III status for their EE diagnosis only

• Patient must have fasted according to CCHMC policy

• Patient's legally authorized representative has given written informed consent to participate in the study and, when appropriate, the subject has given assent to participate

Exclusion Criteria:

• Patients less than a year old and greater than 12 years old

• Patients undergoing therapeutic upper endoscopy

• Patients with an ASA physical status III or greater (other than EE patients)

• Patients with history of allergy to propofol, any other drug in the protocol, or eggs (exclusive of egg allergies identified only by skin testing or manifested only by gastrointestinal symptoms)

• Patients with personal or family history of malignant hyperthermia

• Obese patients (Body mass index more than 95th percentile for age)

• Patients with significant airway abnormalities (e.g., trisomy 21, craniofacial syndromes, sub-glottic stenosis, tracheomalacia, tracheostomy)

• Patients with history of obstructive sleep apnea

• Patient receiving sedative premedication

• Patient previously treated under this protocol

• Patients with symptoms of an active upper respiratory infection

• Patients with history of coagulopathy

• Patients with esophageal varices or gastrointestinal bleeding