Compare the Difference of P4 Concentration in Serum and Endometrium After Vaginal and IM P Administration
Status:
Completed
Trial end date:
2012-02-01
Target enrollment:
Participant gender:
Summary
Crinone is a micronized progesterone gel which is administrated via vaginal route and
targeted drug delivery to uterine (first uterine pass effect) with lower serum concentration.
This study is to investigate the difference of progesterone concentration in serum and
endometrium after administration with crinone and intramuscular progesterone.
The study will be conducted as a single centre, randomized, active controlled study.
Recruitment duration will be 6-8 months long. Day 1 of Crinone administration will be the
baseline. On Day 7 of Crinone administration endometrial tissue will be taken for P4 test.
Last visit will be at 3-5 days after withdraw bleeding.