Compare Ticagrelor vs Clopidogrel on the Reduction of Arterial Stiffness and Wave Reflectionsin Patients With CAD.
Status:
Completed
Trial end date:
2018-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to investigate the potential acute and chronic effect of
ticagrelor versus clopidogrel on arterial stiffness and other vascular risk markers of
interest, the study will consist of two periods: a 24-hour ACUTE period where 60 subjects
with an indication for coronary angiography (CA) with or without percutaneous coronary
intervention (PCI) will be included, and a 30-day CHRONIC period where approximately 60
subjects that will undergo PCI will be included and studied (refer to Section 3 'Study Plan
and Procedures'). The primary objective of this study is to compare ticagrelor versus
clopidogrel regarding their effect on arterial stiffness as assessed by PWV, at 3 hours after
the loading dose of each regimen, in eligible subjects with CAD.