Overview

Compare Pharmaceutical Economics and Efficacy of Sevoflurane With Low Fresh Gas Flow Balanced Anesthesia, Propofol Target Controlled Infusion Anesthesia and Propofol Induction Sevoflurane Maintenance Anesthesia

Status:
Completed

Trial end date:
2011-05-01

Target enrollment:
0

Participant gender:
All

Summary

This study is being performed to compare the cost of anesthetic techniques with sevoflurane (low fresh gas flow balanced anesthesia) versus propofol (target controlled infusion [TCI]) versus propofol induction and sevoflurane maintenance anesthesia in subjects undergoing elective laparoscopic surgery with predicted anesthesic use between 1 and 3 hour duration.

Phase:

Phase 4

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Abbott

Collaborator:

Rundo International Pharmaceutical Research & Development Co.,Ltd.

Treatments:

Anesthetics
Propofol
Sevoflurane

Criteria

Inclusion Criteria

1. Men or women, aged from 18 to 65

2. ASA (American Society of Anesthesiologists) physical status (a requirement of the
subject's physical status): I or II

3. Body mass index (weight/height^2) from 16 to 30 kg/m^2

4. Elective laparoscopic surgery requiring general anesthesia managed with endotracheal
intubation

5. Duration of anesthesia use will be greater than or equal to 1 hour, but less than 3
hours in length.

Exclusion Criteria

1. Hypersensitivity or unusual response to any halogenated anesthetics.

2. History of significant cardiovascular, pulmonary, hepatic, renal, central nervous
system or muscular disease.

3. Pre-operative cognitive dysfunction or disabling neuropsychiatric disorders.

4. Need for emergency surgery or surgery requiring additional regional anesthetic
techniques.

5. Need for intracranial surgery, cardio-surgery or thoracic surgery.

6. Subjects inability to cooperate with the anesthetist before administration of the
anesthetic agent.

7. Personal or familial history of malignant hyperthermia.

8. Females who are either pregnant or breast feeding.