Comparative Study of the Effects of Telmisartan and Nebivolol
Status:
Unknown status
Trial end date:
2017-01-01
Target enrollment:
Participant gender:
Summary
Τhe effectiveness of newer angiotensin-II receptor blockers and cardioselective
beta-adrenergic blockers in treatment of arterial hypertension and in improvement of arterial
stiffness has been established in previous studies among the hypertensive population. The
present study is a comparison of the performance of two drugs, telmisartan and nebivolol, in
24h ambulatory blood pressure values and in the degree of arterial stiffness of patients with
stage I arterial hypertension.
Measurements will be carried out with the use of 24-h ambulatory blood pressure measurement
devices and the method of pulse-wave velocity analysis. The effects of telmisartan and
nebivolol are going to be compared for a total time period of 12 months.
The aim of this project is to determine whether the expected decrease in arterial stiffness
of subjects with stage I arterial hypertension can be attributed to the blood pressure fall
solely, or to other factors as well. These factors are possibly dependent on the action of
these drugs on the renin-angiotensin II-aldosterone system (RAAS) or on peripheral
vasodilatory actions.
The present study is going to be the first comparative test of the anti-hypertensive effects
of the two pharmaceutical substances in 12 months' time, and of the elimination of total
cardiovascular risk in terms of primary prevention of cardiovascular attacks.