Comparative Study of Different I-131 Doses in Graves' Disease
Status:
Unknown status
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
Radioactive iodine (RAI) administration is an effective and completely established treatment
modality in hyperthyroidism including Graves' disease. Despite the long experience with
radioiodine for hyperthyroidism, controversy remains regarding the optimal dose of iodine
that is required to achieve long-term euthyroidism. The fixed activity administration method
does not optimize the therapy, giving often too high or too low radiation to the gland, but
the optimal dose per gram of thyroid mass in calculated activity administration method is
also under much debates. This prospective study has been designed in order to compare the
effect of different calculated doses of radioiodine on Graves' disease treatment outcome.