Comparative Study Between Only Vaginal Misoprostol and Vaginal Misoprostol and Estradiol Cream

• Status: Recruiting
• Trial end date: 2022-08-30
• Target enrollment: 0
• Participant gender: Female

Summary

To compare the safety and effectiveness of vaginal misoprostol with combined vaginal misoprostol and estradiol for induction of labour in unfavorable cervix

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Ain Shams University
• Treatments: Estradiol; Misoprostol

Criteria

Inclusion Criteria:

• Gestational age36:41 weeks.

• Singleton pregnancy.

• Absence of labour pain.

• Living fetus with cephalic presentation.

• Fetal weight < 4 k.gs.

• No previous uterine surgical procedures.

• No liquor abnormalities.

• Bishop score < 5.

Exclusion Criteria:

• - Multiple gestations. one of the contraindications of induction of labor as it may cause rupture of the uterus.

• Liquor abnormalities.one of contraindications of induction of labor as it may cause fetal distress.

• Abnormal umbilical artery Doppler indices or non-stress test as these indicate fetal distress.

• Fetal weight > 4 kgs.as macrosomia is an indication of caesarean section for fear of shoulder dystocia .

• Previous uterine surgery.contraindication of labor induction for fear of rupture uterus.

• Asthmatic patient or women with allergy to prostaglandins or steroidal.

• Non-vertex presentation.contraindication of labor induction as it may cause rupture uterus.

• Fetal or maternal complications that might cause cesarean section.

• Intrauterine fetal death.often induction of labor in women with a dead fetus is performed before term when the uterus may be less responsive to uterotonics than it is at term and this will affect the results of the study