Comparative Study Between Combined Vaginal Misoprostol

• Status: Active, not recruiting
• Trial end date: 2021-10-01
• Target enrollment: 0
• Participant gender: Female

Summary

"Comparative study between Combined Vaginal Misoprostol with Isosorbide-5-Mononitrate

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Cairo University
• Treatments: Misoprostol

Criteria

Inclusion Criteria:

• - Maternal Age 18 - 35 years.

• Gestational age first trimester of pregnancy (between 5-13 weeks).

• Missed abortion confirmed by ultrasound.

• Singleton pregnancy.

• Normal uterus and cervix on clinical examination.

• Cervix is not dilated.

• No vaginal bleeding.

Exclusion Criteria:- Evidences suggesting start of spontaneous abortion and previous trial to induce abortion.

• Presence of uterine contraction or bleeding,

• Multi-fetal pregnancy.

• Suspicion of septic abortion.

• History of Previous cervical surgery or manipulation. Ex: cervical tear , cervical cauterization .

• Uterine anomaly.

• Presence of IUD( intrauterine device) in situ

• Underlying medical diseases.Ex:diabetes mellitus,hypertension

• History of allergy or adverse effects to vaginally administered medication e.g. isosorbide -5- mononitrate

• Those unwilling to participate in the trial

• Higher order cesarean section(more than three