Comparative Evaluation of A-CP HA Kit, Hyaluronic Acid and Placebo for the Treatment of Knee Osteoarthritis
Status:
Recruiting
Trial end date:
2022-04-01
Target enrollment:
Participant gender:
Summary
Hyaluronic acid (HA) is a major component of synovial fluid, to which it confers viscosity
and elasticity. It has been shown that the rheological properties of the synovial fluid
decrease in patients with osteoarthritis. Intra-articular injections of hyaluronic acid
represents a commonly used therapeutic option to relieve osteoarthritic symptoms, by exerting
a mechanical action on cartilaginous structures of the joints, thus leading to reduced pain
and improved joint function.
Platelet-rich Plasma is an autologous product prepared from the patient's own blood.
Potential benefits of platelet-rich plasma for the treatment of cartilage defects have been
suggested by many in vitro and animal studies. There are an increasing number of clinical
studies assessing the benefits of platelet rich plasma in the treatment of osteoarthritis,
showing that platelet rich plasma improves symptoms with no serious adverse events reported.
On the basis of the above, HA and platelet-rich plasma have the potential to provide added
benefits in osteoarthritis symptoms when combined, in particular in patients who have had
previous intra-articular HA treatment but who are still experiencing pain. Preliminary
evidence to this effect was presented at the 2014 Annual Congress of the French Rheumatology
Society by a group of French investigators. Renevier and Marc enrolled patients who had not
experienced adequate symptom relief from previous intra-articular HA treatment and treated
them with HA plus platelet-rich plasma prepared using A-CP HA Kit. Of the 71 patients
treated, approximately 90% were classified as responders based on the OMERACT-OARSI criteria.
The A-CP HA Kit allows for the preparation of a homogenous solution of platelet-rich plasma
and HA, intended to be injected intra-articularly for the treatment of pain in
osteoarthritis. In patients who had previous intra-articular HA treatment but who are still
experiencing pain, treatment with HA plus platelet rich plasma could provide a safe and
reproducible option before surgery.