Comparative Efficacy of Different Mebendazole Polymorphs in the Treatment of Soil-transmitted Helminth Infections
Status:
Completed
Trial end date:
2011-06-01
Target enrollment:
Participant gender:
Summary
Mebendazole tablets which are produced by most pharmaceutical manufacturers, including the
State Pharmaceutical Manufacturing Corporation (SPMC) of Sri Lanka, contain a mixture of
polymorphs A and C. However, there is some evidence to show that mebendazole polymorph C is
the only form effective against the soil-transmitted helminths. This protocol describes a
stratified, randomized, placebo-controlled trial that examined the efficacy of different
mebendazole polymorphs produced by the SPMC in the treatment of hookworm infections.