Comparative Effectiveness of 30%TSC and Heparin Lock Solution in Hemodialysis Catheters

• Status: Completed
• Trial end date: 2014-07-01
• Target enrollment: 0
• Participant gender: All

Summary

BACKGROUND: Central venous catheters (CVC) are the only option when hemodialysis is needed for patients without definitive vascular access. However, CVC use is associated with complications such as infection, thrombosis, and dysfunction, leading to higher mortality and expenditures. The aim of this study was to compare the effectiveness of 30% trisodium citrate (TSC30%) with heparin as CVC lock solution in preventing catheter-related bloodstream infections (CRBSI) and dysfunction in hemodialysis patients. METHODS: Randomized, double-blind controlled trial comparing the event-free survival of non-tunneled CVC locked with heparin or TSC30% in adult hemodialysis patients.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Catholic University of Pelotas
• Treatments: Calcium heparin; Citric Acid; Heparin; Pharmaceutical Solutions

Criteria

Inclusion Criteria:

• patients older than 18 years and

• with chronic or acute renal failure and

• requiring hemodialysis through a catheter.

Exclusion Criteria:

• patients admitted to the intensive care ward,

• receiving a tunneled catheter,

• patients with suspected heparin-induced thrombocytopenia,

• patients with allergy to heparin or TSC30%,

• patients with systemic or localized infection

• pregnant women