Comparative Assessment of the Clinical Utility of Ovarian Stimulation With Menotropin Versus Menotropin Plus GnRH Antagonist

• Status: Completed
• Trial end date: 2009-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

To assess the effectiveness of protocols of ovarian hyperstimulation combining urinary gonadotrophins + GnRH antagonist vs urinary gonadotrophins, to achieve clinical pregnancy in females undergoing intrauterine insemination.

Study hypothesis: protocols combining urinary gonadotrophins + GnRH antagonist should be more effective than monotherapy.

• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Ferring Pharmaceuticals
• Collaborator: Ferring SAU

Criteria

Inclusion Criteria:

• Women aged 18-36 years

• Body mass index (BMI) between 18 and 26

• Prolactin within the laboratory normal range

• Couples affected by sterility able to treat by IUI (intrauterine insemination)

• Patients undergoing Menopur® treatment

• Normal thyroid function

• Regular menses (21-35 days)

• Couples willing to participate in the study that have signed the informed consent form

• Seminal sample REM>3 million

Exclusion Criteria:

• Two previous ART (assisted reproductive technology) cycles without ongoing pregnancy

• Policystic ovarian syndrome

• Evidence of significant bacterial infection in the seminogram of the couple in the preceding 6 months