This project is being undertaken to test the hypothesis that implementing a community based
package of care for women with hypertensive disorders of pregnancy will result in overall
improvement in maternal and neonatal outcomes. This is based on the premise that there are
three main modifiable reasons why women (and their fetuses/newborns) die due to pregnancy
complications: 1) delays by the woman herself in recognizing the seriousness of her
condition; 2) delays in her being assessed and then transported to a center capable of
providing effective and life-saving interventions; and 3) delays in the health facility in
providing those interventions. The treatments for pre-eclampsia that are poorly accessed in
LMIC are 1) magnesium sulfate (MgSO4) for prevention and treatment of the grand mal seizures
of eclampsia; 2) oral antihypertensive medication to lower maternal BP to reduce the risk of
stroke.
The CLIP pilot and definitive cRCT will investigate whether the community level intervention
including implementation of the CLIP package (oral antihypertensive therapy when indicated,
intramuscular (i.m.) MgSO4 when indicated; and appropriate referral to an CEmOC facility when
indicated) of care will reduce the incidence of all-cause maternal morbidity and mortality.
Phase:
N/A
Details
Lead Sponsor:
University of British Columbia
Collaborators:
Aga Khan University Bill and Melinda Gates Foundation Centro de Investigacao em Saude de Manhica Jawaharlal Nehru Medical College Olabisi Onabanjo University