This randomized clinical trial was to compare the effectiveness of prednisone 2mg/kg/day for
3 days vs. dexamethasone 0.6mg/kg for 1 day for treatment of children with mild or moderate
croup. It was conducted in a practice-based research network of community pediatricians in
the St. Louis area. Outcomes included additional health care for croup, duration of symptoms,
nights of disturbed sleep, parental stress, missed work days, and adverse events. Our
hypothesis was that community-based treatment of children with mild or moderate croup with
multiple doses of prednisone is superior to a single dose of dexamethasone.
Phase:
Phase 4
Details
Lead Sponsor:
Washington University School of Medicine
Collaborator:
Washington University Pediatric and Adolescent Ambulatory Research Consortium