Comfort and Antimicrobial Efficacy of Chlorhexidine vs Betadine for Intravitreal Injections

• Status: Unknown status
• Trial end date: 2019-05-06
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this prospective interventional study is to compare patient experience, ocular surface irritation, and bacterial colony counts and microbial spectrum between povidine iodine and aqueous chlorhexidine as ocular surface antiseptic prior to intravitreal injection

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: MidAtlantic Retina
• Treatments: Anti-Bacterial Agents; Anti-Infective Agents; Cadexomer iodine; Chlorhexidine; Chlorhexidine gluconate; Iodine; Povidone-Iodine

Criteria

Inclusion Criteria:

• Current patient of the Wills Eye Hospital Retina Service including all Mid Atlantic Retina offices

• Clinical indication of bilateral intravitreal injection as determined by the treating retina specialist for a diagnosis of age-related macular degeneration, diabetic macular edema, proliferative retinopathy or macular edema associated with retina vein occlusion.

• Age greater than 18.

Exclusion Criteria:

• Documented allergy to PI or AC

• Current diagnosis of infectious keratitis

• History of unilateral contact lens wear in the past 30 days

• Current unilateral use of prescription eye drops.