Comedone Extraction and Oral Doxycycline In The First Line Treatment of Moderate Acne Vulgaris

• Status: Completed
• Trial end date: 2015-10-14
• Target enrollment: 0
• Participant gender: All

Summary

The objective of the study was to evaluate the effectiveness of comedone extraction compared to oral antibiotics as the main therapy of moderate acne vulgaris (MAV); and to determine the expression of HIF-1 alpha by examining the immunohistochemistry and ELISA as a sign of hypoxia/anoxia in MAV lesion. This was a randomized, placebo-controlled clinical trial that was performed in 2015 at three different dermatology clinics in Indonesia, Cipto Mangunkusumo Hospital Jakarta, Gatot Soebroto Army Hospital Jakarta, and PT. Mattel Indonesia, Cikarang. One hundred and twenty eight subjects with moderate acne vulgaris were recruited and randomized to receive either oral doxycycline or comedone extraction for six weeks. Subjects who had acne lesion and the back area were offered skin lesion biopsy to evaluate immunohistochemistry and ELISA before administration of medication. The main outcome was total reduction of inflammatory and non inflammatory lesions, evaluated every two weeks.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Indonesia University
• Treatments: Doxycycline

Criteria

Inclusion Criteria:

• Patients with moderate acne vulgaris based on clinical manifestation of face (20-100 comedones, 15-50 inflammatory lesions, and/or 30-125 total lesions)

• Age range of 15 to 50 years old

Exclusion Criteria:

• History of oral antibiotics consumption within 2 weeks preceding this study

• Usage of topical retinoid in less than previous 2 weeks

• History of systemic retinoid consumption within 3 months preceding this study

• Pregnant of breastfeeding women

• Consuming oral contraception during examination

• Drug allergy or skin manifestation due to side effect of moderate acne vulgaris first line therapy