Combining Donepezil With Perceptual Learning in Normal and Amblyopic Human The Effect of Donepezil on Perceptual Learning in Adult Amblyopia

• Status: Completed
• Trial end date: 2018-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The research deals with amblyopia or lazy eye, a condition that affects about 3% of the population, and results in a variety of visual deficits. Recent work suggests that there is limited neural plasticity in the visual system of adults with amblyopia. This study is aimed at understanding and increasing this plasticity. In this study, the investigators aim to understand how the amblyopic brain learns and how this process is affected by a drug called donepezil, which is sometimes given as a treatment for Alzheimer's disease. The investigators hope that this study will help to identify the chemical components that help the brain to learn, as well as the mechanism of amblyopia. The investigators also plan to test the normal periphery, as control.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Dennis Levi; National Eye Institute (NEI)
• Treatments: Donepezil

Criteria

Subjects with amblyopia

Inclusion Criteria:

• corrected visual acuity being 20/30 or worse in the poorer eye (at least 20/20 in the better eye)

• reduced stereoacuity

• normal retina

Exclusion Criteria:

• with other diagnosed eye diseases

Subjects with normal vision

Inclusion Criteria:

• corrected visual acuity at least 20/20 in each eye

• normal stereoacuity

• normal retina

Exclusion Criteria:

• with other diagnosed eye diseases