Combined Ketamine and eCBT Intervention for PTSD

• Status: Recruiting
• Trial end date: 2022-03-31
• Target enrollment: 0
• Participant gender: All

Summary

An open label RCT assessing the efficacy of a combined treatment approach for PTSD, using Ketamine infusions and online Cognitive Behavioural Therapy.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Queen's University
• Treatments: Ketamine

Criteria

Inclusion Criteria:

• Diagnosis of PTSD by a psychiatrist on the team using the Clinician Administered PTSD Scale (CAPS-5) with a score of at least 50 and a medium presentation.

• Patients will have received at least 2 different types of prior treatment, both of which produced less than a 50% reduction in the participant's symptoms.

• Participants with hypertension or cardiovascular disease must be receiving stable treatment to participate.

• Participants must speak and read English, and will have consistent and reliable access to the internet.

• Patients with suicidal ideation will be included.

• Patients with a history of substance abuse will be included (except for opioid use disorder).

Exclusion Criteria:

Hypomanic/manic episodes, bipolar disorder, acute psychosis, opioid use disorder, treatment with Naltrexone, pregnancy, postpartum, breastfeeding, untreated hypertension, cardiovascular disease, ASPD, active homicidal ideation, and general noncompliance with the study protocol.