Combined IV and Topical TXA in Major Spine Surgery
Status:
Not yet recruiting
Trial end date:
2022-10-01
Target enrollment:
Participant gender:
Summary
This is a randomized study. The purpose of this study is to evaluate the effect of tranexamic
acid in patients undergoing multilevel spine surgery. 75 patients undergoing multi-level
spine surgery will be enrolled at Mount Sinai West. Study participation will last from the
time of pre-operative evaluation to the time of discharge from hospital. Specifically, the
study team will compare tranexamic acid given only intravenously vs. given both topically and
intravenously vs. given only intravenously but at a higher dosage. The study team
hypothesizes that patient who received combined topical and intravenous TXA (low dose) have
similar or decreased overall blood loss postoperatively compared to patient who received high
or low dose intravenous TXA alone.