Combined Atropine With Orthokeratology in Childhood Myopia Control (AOK) -A Randomized Controlled Trial
Status:
Completed
Trial end date:
2021-05-08
Target enrollment:
Participant gender:
Summary
This study aims to compare effects in retardation of myopia progression of combined ortho-k
and 0.01% atropine therapy with those of ortho-k alone.Myopia control methods mainly focus on
optical and pharmaceutical interventions . Currently, overnight-wear orthokeratology
(ortho-k), is used extensively in Hong Kong with approximately 50% retardation effect.
Pharmaceutical methods have focused on the use of atropine eye drops to slow myopic
progression.The use of 1% atropine was limited by the manifestation of side effects and
rebound effect.However, both side effect and rebound effect was minimal with 0.01%
atropine.It was suggested that 0.01% was the optimum concentration for controlling myopia.The
mechanisms of neither ortho-k nor atropine in myopia control are fully understood.It is
believed that ortho-k and atropine act via different mechanisms.It is possible that by
combining these two methods, additional retardation of myopia progression could be achieved.