Combined Antihypertensive Therapy and Sexual Dysfunction
Status:
Unknown status
Trial end date:
2010-11-01
Target enrollment:
Participant gender:
Summary
This randomized,active controlled study aimed to compare the effects on sexual function of
treatment with combined antihypertensive drugs.
The researchers hypothesize that:
1. Both felodipine-irbesartan combination and felodipine-metoprolol combination are
effective in lowing blood pressure in patients with essential hypertension.
2. Felodipine-metoprolol combination induces a worse sexual function and a reduction of sex
hormone,whereas felodipine-irbesartan combination does not impair sexual function and
does not change hormone levels.
3. Oxidative stress decline after both combination regimens. Felodipine-irbesartan
combination has a greater impact on oxidative stress indicators than
felodipine-metoprolol combination.