Combined Antidepressant and Behavioural Intervention
Status:
Recruiting
Trial end date:
2023-05-28
Target enrollment:
Participant gender:
Summary
A body of evidence from both animal and human research suggests that antidepressant drugs may
induce early changes in emotional processing that interact with environmental factors to
produce a later change in mood. This experimental medicine study will examine the effect of
citalopram on emotional cognition under different environmental conditions (as manipulated by
the presence or absence of behavioural activation training). Participants will be
administered either citalopram or placebo over the course of two weeks. Citalopram will be
taken either alone or in combination with behavioural activation training.
Phase:
N/A
Details
Lead Sponsor:
University of Oxford
Collaborator:
National Institute for Health Research, United Kingdom