Overview

Combined Administration of Intravenous and Topical Tranexamic Acid in Total Knee Arthroplasty

Status:
Unknown status
Trial end date:
2015-06-01
Target enrollment:
0
Participant gender:
All
Summary
This prospective randomized controlled trial was conducted To compare the efficacy of TNA in terms of total blood loss and the allogenic transfusion rate among the three study groups; intravenous alone, combined intravenous and low dose topical TNA and combined intravenous and high dose topical TNA. To evaluate the safety of each regimen in view of deep vein thrombosis and venous thromboembolism.
Phase:
Phase 1
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Seoul National University Hospital
Treatments:
Tranexamic Acid
Criteria
Inclusion Criteria:

- patients with diagnosis of primary osteoarthritis

Exclusion Criteria:

- patients with diagnoses other than primary OA

- patients on anticoagulation therapy

- patient with chronic renal failure

- patient with CVA Hx

- Patient with seizure Hx

- Patient with severe CHF

- Patient with acquired or congenital coagulopathy