Combination of Nicotine Replacement Therapy (NRT) and Varenicline to Increase Cessation of Tobacco (CONVICT Study)
Status:
Completed
Trial end date:
2011-10-01
Target enrollment:
Participant gender:
Summary
Varenicline and nicotine replacement therapy (NRT) are both effective smoking cessation
treatments. Anecdotally smokers who are finding their quit attempt difficult have reported
benefiting from adding NRT to varenicline. This proof-of-principle placebo-controlled
double-blind study will examine whether combining NRT and varenicline provides better
withdrawal and craving relief than varenicline alone. A total of 120 smokers would be
randomised to receive varenicline +15mg/16hr patch or varenicline + placebo patch. All
participants will receive standard NHS Stop Smoking Service support. The primary outcome
would be ratings of craving and withdrawal discomfort 24 hours and one week after the target
quit date.