Combination of Magnesium and Lidocaine for the Pretreatment of Pain That is Caused by the Injection of Propofol
Status:
Completed
Trial end date:
2012-04-01
Target enrollment:
Participant gender:
Summary
Since the introduction of propofol into routine anesthesia practice, the phenomena of pain on
injection has plagued anesthesia providers. Propofol, an unstable phenol, triggers the
release of bradykinin on injection. This release causes a painful burning sensation in the
patient at the site of injection. Anesthesia providers have attempted a large number of
remedies to prevent this pain on injection. Previously explored ideas include injecting
propofol into larger veins, warming of the hand with hot packs, and intravenous pretreatment
with numerous other medications. Currently, pretreatment with lidocaine is commonly
administered to prevent propofol injection pain. No studies to date have looked at the
combination of lidocaine and magnesium in a single syringe for the pretreatment of pain on
injection caused by propofol. In addition, the administration protocols that have been
studied thus far do not mirror clinical practice at the University of Wisconsin. The
investigators propose studying the use of magnesium and lidocaine in a single syringe for
pretreatment of propofol related pain on injection.