Overview

Combination of Docetaxel, Cisplatin, and Capecitabine (DCX) in the Treatment of Nasopharyngeal Carcinoma

Status:
Completed
Trial end date:
2016-04-01
Target enrollment:
0
Participant gender:
All
Summary
The standard treatment strategy for locally advanced (stage IVA) and metastatic (stage IVB) nasopharyngeal carcinoma has not been defined yet. Generally induction chemotherapy is given to those patients in order to shrink the tumor volume and facilitate the following radiation therapy. Thus, in this study, the investigators use the combination of Docetaxel+Cisplatin+Xeloda (DCX) to treat locally advanced and metastatic nasopharyngeal carcinoma patients, in order to evaluate the efficacy and safety profiles.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Sun Yat-sen University
Treatments:
Capecitabine
Cisplatin
Docetaxel
Criteria
Inclusion Criteria:

- stage IVA and IVB nasopharyngeal carcinoma

- at lease one measurable lesion

- receive no chemotherapy or radiotherapy before

- Eastern CooperativeOncology Group performance status of 0 to 2.

- Adequate hematologic function (eg, white blood cell ≥ 3×10e9/l,neutrophils count
≥1.5×10e9/L, and platelet count≥ 100×10e9/L),renal function (eg, serum creatinine≤1.5
mg/dL and creatinine clearance ≥50 mL minute), and hepatic function (e.g, total
bilirubin≤ 2 times the upper limit of normal and aspartate and alanine transaminase
levels ≤ 3 times the upper limit of normal)

Exclusion Criteria:

- mismatch the inclusion criteria

- previous or concomitant malignancies and any coexisting medical problems that could
cause poor compliance with the study protocol.

- allergy to any of these three drugs