Overview

Combination Therapy in Patients With Relapsing-Remitting Multiple Sclerosis (MS)CombiRx

Status:
Completed
Trial end date:
2013-03-01
Target enrollment:
0
Participant gender:
All
Summary
This is for a randomized clinical trial (RCT) to determine if the combined use of interferon beta-1a (IFN) and glatiramer acetate (GA) is a measurably better therapy than either agent used individually in patients with relapsing-remitting (RR) multiple sclerosis (MS).
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Fred Lublin
Collaborator:
National Institute of Neurological Disorders and Stroke (NINDS)
Treatments:
(T,G)-A-L
Glatiramer Acetate
Interferon beta-1a
Interferon-beta
Interferons
Criteria
Inclusion Criteria:

- Male and female subjects between the ages of 18 and 60 years, inclusive.

- Diagnosis of relapsing-remitting MS by either the Poser or McDonald criteria.

- Expanded Disability Status Scale (EDSS) score between 0 and 5.5, inclusive.

- At least 2 exacerbations in the prior three years; one exacerbation may utilize the
McDonald MRI criteria for dissemination in time (a new gadolinium [Gd]-enhancing
lesion demonstrated on a scan done at least 3 months following onset of a clinical
attack or a new T2 lesion or Gd-enhancing lesion on a follow-up scan after an
additional 3 months).

- Give written informed consent prior to any testing under this protocol, including
screening tests and evaluations that are not considered part of the subject's routine
care.

Exclusion Criteria:

- Any prior use of interferon beta or glatiramer acetate.

- Acute exacerbation within 30 days of screening.

- Steroids for acute exacerbations (>100 mg/day) within 30 days of study entrance or
chronic systemic steroid use.

- Evidence of progressive MS.

- Use IVIg, azathioprine, methotrexate, cyclosporine, mitoxantrone, cyclophosphamide,
mycophenolate (CellCept) or plasma exchange in the twelve weeks prior to study drug
dosing.

- Any previous treatment with natalizumab (Tysabri, Antegren), cladribine, T cell
vaccine, Campath, daclizumab, rituximab, altered peptide ligand or total lymphoid
irradiation.

- Treatment with 4 aminopyridines in the four weeks prior to study drug dosing.

- Prior treatment with any other investigational drug, unless approved by the Clinical
Coordinating Center (Dr. Lublin).

- Inability to perform the baseline MSFC (timed 25-foot walk, 9-hole peg test [9HPT],
and Paced Auditory Serial Addition Test 3 [PASAT3]).

- Inability to undergo baseline MRI scan.

- History of any significant cardiac, hepatic, pulmonary, or renal disease, immune
deficiency, or other medical conditions that would preclude therapy with interferon
beta, glatiramer acetate, or participation in this study.

- Known history of sensitivity to gadopentetate dimeglumine or mannitol.

- History of a seizure within the 3 months prior to randomization.

- History of suicidal ideation or an episode of severe depression within the 3 months
prior to randomization.

- Abnormal screening blood tests exceeding any of the limits defined below:

- Alanine transaminase (ALT) or aspartate transaminase (AST) greater than two times
the upper limit of normal (i.e., >2 × ULN)

- Total white blood cell count <2,300/mm3

- Platelet count <80,000/mm3

- Creatinine >2 × ULN

- Participation in another experimental clinical trial, without formal approval.

- History of alcohol or drug abuse within the 2 years prior to randomization.

- Female subjects who are currently pregnant, breast-feeding, or plan to become
pregnant.

- For female subjects, unless postmenopausal or surgically sterile, unwillingness to
practice effective contraception, as defined by the investigator, during the study.
The rhythm method is not to be used as the sole method of contraception.

- Unwillingness or inability to comply with the requirements of this protocol including
the presence of any condition that is likely to affect the subject's returning for
scheduled follow-up visits on schedule (any physical, mental, or social condition).