Combination Medications vs. Patch Alone for Medically-Ill Smokers

• Status: Completed
• Trial end date: 2008-01-01
• Target enrollment: 0
• Participant gender: All

Summary

Randomized clinical trial to evaluate a flexibly-dosed-3-medication combination for up to 6 months in smokers with medical illness

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Medicine and Dentistry of New Jersey
• Collaborators: Robert Wood Johnson Foundation; Rutgers Cancer Institute of New Jersey
• Treatments: Bupropion; Nicotine

Criteria

Inclusion Criteria:

• currently smoking at least 10 cigarettes per day (confirmed by high exhaled carbon-monoxide (CO))

• 18 years or older

• interested in quitting within the next 30 days

• one or more pre-defined medical illnesses (including cardiovascular disease, other vascular disease, chronic pulmonary disease, cancer, hypertension, diabetes, hyperlipidemia, and recurrent pulmonary infections)

Exclusion Criteria:

• contraindications to pharmacotherapy (including unstable angina, myocardial infarction within 2 months, severe arrhythmia, seizure disorder, serious mental illness requiring antipsychotic medications)

• current use of other tobacco products (smokeless tobacco, cigars, pipes, etc.), bupropion, clonidine, nortriptyline, or nicotine replacement medications

• unable to give consent