Combination Diuretic Therapy for Acute Decompensated Heart Failure
Status:
Withdrawn
Trial end date:
2015-10-01
Target enrollment:
Participant gender:
Summary
Patients with heart failure are often admitted to the hospital because they have accumulated
excessive amounts of fluid, they become short of breath and congested with fluid. Removing
the excess fluid is necessary to improve the patients symptoms and reduce the risk of being
re-admitted to the hospital. Diuretics ("water pills") are often given through an IV to
accelerate the fluid removal. Furosemide is commonly used for fluid removal, however some
patients do not respond well to the medication. There are other diuretics available that can
work in conjunction with furosemide and increase the rate of fluid removal. The other "water
pills" have slightly different mechanisms of action in the body compared to furosemide and
when combined they may increase fluid removal.
The investigators hypothesize that adding chlorothiazide to furosemide will result in quicker
and more effective fluid removal in heart failure patients.