Combination Chemotx in Treating Children or Adolescents With Newly Diagnosed Stg III or Stg IV Lymphoblastic Lymphoma

• Status: Completed
• Trial end date: 2015-03-31
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. It is not yet known which regimen of combination chemotherapy is most effective for lymphoblastic lymphoma.

PURPOSE: This randomized phase III trial is studying different regimens of combination chemotherapy to compare how well they work in treating children or adolescents with newly diagnosed stage III or stage IV lymphoblastic lymphoma.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Children's Oncology Group
• Collaborator: National Cancer Institute (NCI)
• Treatments: 6-Mercaptopurine; Asparaginase; BB 1101; Calcium, Dietary; Cyclophosphamide; Cytarabine; Daunorubicin; Dexamethasone; Dexamethasone 21-phosphate; Dexamethasone acetate; Doxorubicin; Leucovorin; Levoleucovorin; Liposomal doxorubicin; Mercaptopurine; Methotrexate; Prednisone; Thioguanine; Vincristine

Criteria

DISEASE CHARACTERISTICS:

• Newly diagnosed disseminated lymphoblastic lymphoma or localized lymphoblastic lymphoma*

• Less than 25% tumor cells in the bone marrow

• Previously untreated (prior intrathecal cytarabine allowed if protocol therapy begins within 72 hours)

• Stage III or IV disease

• NOTE: *Localized lymphoblastic lymphoma is closed to accrual as of 10/2005

PATIENT CHARACTERISTICS:

Age:

• 1 to 30

Performance status:

• Not specified

Life expectancy:

• Not specified

Hematopoietic:

• Not specified

Hepatic:

• Not specified

Renal:

• Not specified

Cardiovascular:

• Adequate cardiac function

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• See Disease Characteristics

Endocrine therapy:

• Emergency steroid therapy (if required) must be started within 72 hours prior to protocol therapy

Radiotherapy:

• Emergency radiotherapy (if required) must be started within 72 hours prior to protocol therapy

Surgery:

• Not specified

Other:

• No other prior therapy except for emergency treatment of airway obstruction and/or superior vena cava syndrome