Combination Chemotherapy in Treating Young Patients With Relapsed or Refractory Acute Leukemia
Status:
Completed
Trial end date:
2013-11-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as clofarabine, topotecan, vinorelbine, thiotepa,
and dexamethasone, work in different ways to stop the growth of cancer cells, either by
killing the cells or by stopping them from dividing. Giving more than one drug (combination
chemotherapy) may kill more cancer cells.
PURPOSE: This phase I trial is studying the side effects and best dose of clofarabine when
given together with topotecan, vinorelbine, thiotepa, and dexamethasone in treating young
patients with relapsed or refractory acute leukemia.