Overview

Combination Chemotherapy in Treating Patients With Previously Untreated Advanced Hodgkin's Lymphoma

Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. It is not yet known which combination chemotherapy regimen is more effective in treating patients who have advanced Hodgkin's lymphoma. PURPOSE: Randomized phase III trial to compare the effectiveness of two different combination chemotherapy regimens in treating patients who have advanced Hodgkin's lymphoma.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Mount Vernon Cancer Centre at Mount Vernon Hospital
Treatments:
Bleomycin
Dacarbazine
Doxorubicin
Etoposide
Liposomal doxorubicin
Mechlorethamine
Prednisone
Vinblastine
Vincristine
Criteria
DISEASE CHARACTERISTICS:

- Histologically confirmed Hodgkin's lymphoma (any sub-type)

- Stage IB, IIB, IIIA, IIIB, or IV OR

- Stage IA or IIA with locally extensive disease (e.g., bulky mediastinal disease
(e.g., greater than 0.33 of the maximum transthoracic diameter on routine chest
X-ray or at least 2 extranodal sites of disease))

PATIENT CHARACTERISTICS:

Age:

- 18 to 60

Performance status:

- Not specified

Life expectancy:

- Not specified

Hematopoietic:

- Complete blood count normal unless directly due to Hodgkin's lymphoma

Hepatic:

- Hepatic function normal unless directly due to Hodgkin's lymphoma

Renal:

- Renal function normal unless directly due to Hodgkin's lymphoma

Cardiovascular:

- No pre-existing cardiac disease

Pulmonary:

- No pre-existing pulmonary disease

Other:

- Not pregnant

- Fertile patients must use effective contraception during and for six months after
study

- HIV negative

- No other prior malignancy except basal cell or squamous cell skin cancer

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- Not specified

Chemotherapy:

- Not specified

Endocrine therapy:

- Not specified

Radiotherapy:

- Not specified

Surgery:

- Not specified

Other:

- No prior therapy for Hodgkin's lymphoma