Overview

Combination Chemotherapy in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma

Status:
Completed
Trial end date:
2007-04-18
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells. PURPOSE: Phase II trial to study the effectiveness of different regimens of combination chemotherapy in treating patients with newly diagnosed mantle cell lymphoma.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
M.D. Anderson Cancer Center
Collaborator:
National Cancer Institute (NCI)
Treatments:
BB 1101
Cyclophosphamide
Cytarabine
Dexamethasone
Dexamethasone 21-phosphate
Dexamethasone acetate
Doxorubicin
Lenograstim
Liposomal doxorubicin
Methotrexate
Vincristine
Criteria
DISEASE CHARACTERISTICS:

- Histologically confirmed previously untreated nodular or diffuse mantle cell lymphoma
or their blastic variant

- No CNS involvement

- Not a candidate for stem cell transplantation or refuses one

PATIENT CHARACTERISTICS:

Age:

- 16 and over

Performance status:

- Zubrod 0-2

Life expectancy:

- Not specified

Hematopoietic:

- Absolute neutrophil count greater than 1,000/mm^3*

- Platelet count greater than 100,000/mm^3* NOTE: * Unless lymphoma involvement

Hepatic:

- Bilirubin less than 1.5 mg/dL (unless lymphoma involvement)

Renal:

- Creatinine less than 2.0 mg/dL (unless lymphoma involvement)

Cardiovascular:

- Cardiac ejection fraction at least 50% (for patients over age 40)

Other:

- Must be willing to receive blood transfusion

- Not pregnant or nursing

- Fertile patients must use effective contraception

- HIV negative

- No other co-morbid medical or psychiatric illness that would preclude treatment

- No prior or concurrent malignancy with poor prognosis (less than 90% probability of
survival at 5 years)

PRIOR CONCURRENT THERAPY:

Biologic therapy

- See Disease Characteristics

Chemotherapy

- Not specified

Endocrine therapy

- Not specified

Radiotherapy

- Not specified

Surgery

- Not specified