Combination Chemotherapy in Treating Patients With Burkitt's Lymphoma or Burkitt's Leukemia

• Status: Completed
• Trial end date: 2008-12-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.

PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating patients who have Burkitt's lymphoma or Burkitt's leukemia.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Medical Research Council
• Treatments: Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Ifosfamide; Leucovorin; Levoleucovorin; Liposomal doxorubicin; Methotrexate; Vincristine

Criteria

DISEASE CHARACTERISTICS:

• Diagnosis of diffuse B-cell lymphoma in a nodal or an extranodal site

• CD20 and CD79 positive

• 100% expression of Ki67 (MIB1) in all of the tumor cells OR

• Diagnosis of bone marrow replacement/leukemia comprising mature B-cell lymphoma

• sIg and CD19 positive

• CD34 and Tdt negative

• Patients in the low-risk group must meet at least 3 of the following criteria:

• Normal lactate dehydrogenase (LDH) level

• WHO performance status 0-1

• Ann Arbor stage I or II

• No more than 1 extranodal site (e.g., bone marrow, gastrointestinal tract, or CNS)

• Patients in the high-risk group must meet at least 2 of the following criteria:

• Raised LDH level

• WHO performance status 2-4

• Ann Arbor stage III or IV

• More than 1 extranodal site

PATIENT CHARACTERISTICS:

Age:

• 16 and over

Performance status:

• See Disease Characteristics

Life expectancy:

• Not specified

Hematopoietic:

• See Disease Characteristics

Hepatic:

• See Disease Characteristics

Renal:

• Not specified

Other:

• No mental or physical status that would preclude study

• No other disease or prior malignancy that would preclude study

• HIV negative

• Not pregnant

• Negative pregnancy test

• Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• No prior chemotherapy except 1 course of preinduction chemotherapy (e.g., CHOP [cyclophosphamide, doxorubicin, vincristine, and prednisone] or a related regimen)

Endocrine therapy:

• Not specified

Radiotherapy:

• No prior radiotherapy

Surgery:

• Not specified