Combination Chemotherapy in Treating Patients With Advanced Stomach Cancer

• Status: Completed
• Trial end date: 2003-07-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. It is not yet known which combination chemotherapy regimen is most effective in treating advanced stomach cancer.

PURPOSE: Randomized phase II trial to compare the effectiveness of different regimens of combination chemotherapy in treating patients who have advanced stomach cancer.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Swiss Group for Clinical Cancer Research
• Treatments: Cisplatin; Docetaxel; Epirubicin; Fluorouracil

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed gastric carcinoma not amenable to curative surgery or in relapse after primary surgical resection

• Locally advanced disease (i.e., measurable locoregional lymph nodes) OR

• Metastatic disease

• Bidimensionally measurable disease

• At least 10 mm X 20 mm by chest x-ray or physical examination

• At least 10 mm X 10 mm by CT scan

• No CNS metastasis

PATIENT CHARACTERISTICS:

Age:

• 18 to 70

Performance status:

• 0-1

Life expectancy:

• Greater than 12 weeks

Hematopoietic:

• WBC count at least 4,000/mm^3

• Platelet count at least 100,000/mm^3

Hepatic:

• Bilirubin no greater than 1.25 times upper limit of normal (ULN)

• AST/ALT no greater than 2.5 times ULN

• Alkaline phosphatase no greater than 5 times ULN

Renal:

• BUN normal

• Creatinine normal

• Creatinine clearance at least 60 mL/min

• No severe hypercalcemia

Cardiovascular:

• No unstable cardiac disease requiring treatment

• No congestive heart failure

• No angina pectoris even if medically controlled

• No significant arrhythmias

• No prior myocardial infarction unless ejection fraction at least 50% by MUGA scan or echocardiogram

Neurologic:

• No prior significant neurologic or psychiatric disorders, including psychotic disorders, dementia or seizures that would preclude study

• No peripheral neuropathy of any origin (alcohol, etc.) greater than grade 1

Other:

• Fertile patients must use adequate contraception

• No prior malignancy except basal cell skin cancer or adequately treated carcinoma in situ of the cervix

• No active uncontrolled infection

• No other serious illness or medical condition that would preclude study participation

• No contraindication to corticosteroid use

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• Not specified

Chemotherapy:

• No prior palliative chemotherapy

• At least 12 months since prior adjuvant or neoadjuvant chemotherapy

• No prior taxanes

• Prior fluorouracil allowed in bolus form only

• Prior cumulative dose of adjuvant or neoadjuvant cisplatin no greater than 300 mg/m2

Endocrine therapy:

• Prior or concurrent prednisone (or equivalent) allowed for prophylaxis, acute hypersensitivity reactions, or chronic therapy (greater than 6 months) at doses no greater than 20 mg

Radiotherapy:

• Not specified

Surgery:

• See Disease Characteristics

Other:

• No other concurrent experimental drugs

• No other concurrent anticancer therapies

• At least 30 days since treatment in prior clinical trial