Combination Chemotherapy and Radiation in Treating Patients With Stage III or IV Head and Neck Cancer (Paradigm Trial)
Status:
Completed
Trial end date:
2012-04-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as docetaxel, cisplatin, fluorouracil, and
carboplatin, work in different ways to stop tumor cells from dividing so they stop growing or
die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy
with radiation therapy may kill more tumor cells. It is not yet known which regimen of
chemotherapy and radiation therapy is most effective in treating head and neck cancer.
PURPOSE: Randomized phase III trial to compare the effectiveness of two different regimens of
chemotherapy and radiation therapy in treating patients who have stage III or stage IV head
and neck cancer.