Combination Chemotherapy and Cyclosporine Followed by Focal Therapy for Bilateral Retinoblastoma
Status:
Active, not recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as carboplatin, etoposide, and vincristine, work
in different ways to stop the growth of tumor cells, either by killing the cells or by
stopping them from dividing. Sometimes when chemotherapy is given, it does not stop the
growth of tumor cells. The tumor is said to be resistant to chemotherapy. Giving cyclosporine
together with chemotherapy may reduce drug resistance and allow the tumor cells to be killed.
Cryotherapy kills tumor cells by freezing them. Laser therapy uses light to kill tumor cells.
Giving combination chemotherapy together with cyclosporine followed by cryotherapy and/or
laser therapy may be an effective treatment for retinoblastoma.
PURPOSE: This phase II trial is studying how well giving combination chemotherapy together
with cyclosporine followed by cryotherapy and/or laser therapy works in treating patients
with newly diagnosed retinoblastoma in both eyes.