Combination Chemotherapy With or Without Trastuzumab in Treating Women With Breast Cancer
Status:
Completed
Trial end date:
2009-12-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so
they stop growing or die. Monoclonal antibodies such as trastuzumab can locate tumor cells
and either kill them or deliver tumor-killing substances to them without harming normal
cells. Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known
which regimen of chemotherapy plus radiation therapy with or without trastuzumab is more
effective in treating breast cancer.
PURPOSE: Randomized phase III trial to compare two different chemotherapy regimens plus
radiation therapy with or without trastuzumab in treating women who have breast cancer that
has spread to lymph nodes in the axilla (under the arm).