Combination Chemotherapy With or Without Topotecan in Treating Patients With Newly Diagnosed Localized Ewing's Sarcoma
Status:
Withdrawn
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy, such as vincristine, doxorubicin, cyclophosphamide,
ifosfamide, etoposide, and topotecan, work in different ways to stop the growth of tumor
cells, either by killing the cells or by stopping them from dividing. Giving more than one
drug (combination chemotherapy) may kill more tumor cells. Giving chemotherapy before surgery
may make the tumor smaller and reduce the amount of normal tissue that needs to be removed.
Giving chemotherapy after surgery may kill any tumor cells that remain after surgery. It is
not yet known which combination chemotherapy regimen is more effective in treating Ewing's
sarcoma.
PURPOSE: This randomized phase III trial is studying combination chemotherapy and topotecan
to see how well they work compared with combination chemotherapy alone in treating patients
with newly diagnosed localized Ewing's sarcoma.