Overview

Combination Chemotherapy With or Without Surgery and Radiation Therapy in Treating Patients With Mesothelioma That Can Be Removed By Surgery

Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving combination chemotherapy before surgery may shrink the tumor so that it can be removed. Giving radiation therapy after surgery may kill any tumor cells that remain after surgery. It is not yet known whether combination chemotherapy is more effective with or without surgery and radiation therapy in treating mesothelioma. PURPOSE: This randomized clinical trial is studying combination chemotherapy, surgery, and radiation therapy to see how well they work compared to combination chemotherapy alone in treating patients with mesothelioma that can be removed by surgery.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Institute of Cancer Research, United Kingdom
Criteria
DISEASE CHARACTERISTICS:

- Histologically and immuno-histochemically confirmed malignant mesothelioma

- Resectable disease (T1-3, N0-1, M0) with no distant metastases

- Eligible to undergo extra-pleural pneumonectomy based on British Thoracic Society
guidelines

PATIENT CHARACTERISTICS:

Performance status

- WHO 0-1

Life expectancy

- Not specified

Hematopoietic

- Not specified

Hepatic

- Not specified

Renal

- Normal renal function

Cardiovascular

- Ejection fraction ≥ 40%

Pulmonary

- Predicted post-operative FEV_1 ≥ 40%

- Predicted post-operative DLCO ≥ 40%

- No significant pulmonary hypertension

Other

- No physical or personal condition that would preclude ability to undergo chemotherapy
or post-operative radiotherapy

- No physical or personal condition that would preclude ability to comply with follow-up
requirements

PRIOR CONCURRENT THERAPY:

- Not specified