Overview

Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma

Status:
Completed
Trial end date:
2016-05-01
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage cancer cells. Combining more than one drug with radiation therapy may kill more cancer cells. It is not yet known which combination chemotherapy regimen is most effective in treating Hodgkin's lymphoma. PURPOSE: This randomized phase III trial is studying two different combination chemotherapy regimens and comparing how well they work, with or without radiation therapy, in treating patients with Hodgkin's lymphoma.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Eastern Cooperative Oncology Group
Collaborator:
National Cancer Institute (NCI)
Treatments:
Bleomycin
Cyclophosphamide
Dacarbazine
Doxorubicin
Etoposide
Etoposide phosphate
Imidazole
Liposomal doxorubicin
Mechlorethamine
Podophyllotoxin
Prednisone
Vinblastine
Vincristine
Criteria
Inclusion criteria:

- Histologically proven previously untreated classical Hodgkin's lymphoma

- The following stages are eligible:

- Locally extensive: Stage I-IIA/B with massive mediastinal adenopathy

- Advanced: Stage III or IV

- Measurable or evaluable disease

- Age of 16 and over

- ECOG Performance status 0-2

- Disease-free of prior invasive malignancies for >5 years with the exception of
curatively-treated basal cell or squamous cell carcinoma of the skin or carcinoma in
situ of the cervix

- White blood cell (WBC) at least 4,000/mm³, (unless documented bone marrow involvement)

- Platelet count at least 100,000/mm³ (unless documented bone marrow involvement)

- Bilirubin no greater than 5.0 mg/dL

- Creatinine no greater than 2.0 mg/dL

- Ejection fraction determination recommended if over age 50 and/or have a history of
cardiac disease

- Fertile patients must use effective contraception

- Prior corticosteroids allowed

- Prior surgery allowed

Exclusion criteria:

- Pregnant or nursing

- Prior radiotherapy

- Prior chemotherapy

- Human immunodeficiency virus (HIV) positive