Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma

• Status: Unknown status
• Trial end date: 1969-12-31

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy and kill more tumor cells. It is not yet known if combination chemotherapy is more effective with or without radiation therapy and/or surgery in treating Ewing's sarcoma.

PURPOSE: This randomized phase III trial is studying different combination chemotherapy regimens to see how well they work when given with or without peripheral stem cell transplantation, radiation therapy, and/or surgery in treating patients with Ewing's sarcoma.

• Phase: Phase 3

Details

• Lead Sponsor: University of Leicester
• Collaborators: Children's Cancer and Leukaemia Group; Children's Oncology Group; EBMT Solid Tumors Working Party; European Organisation for Research and Treatment of Cancer - EORTC; Gesellschaft fur Padiatrische Onkologie und Hamatologie - Austria; National Cancer Institute (NCI); Societe Francaise Oncologie Pediatrique; Swiss Group for Clinical Cancer Research
• Treatments: Busulfan; Dactinomycin; Doxorubicin; Etoposide; Ifosfamide; Isophosphamide mustard; Liposomal doxorubicin; Melphalan; Vincristine