Combination Chemotherapy With or Without Metformin Hydrochloride in Treating Patients With Metastatic Pancreatic Cancer
Status:
Terminated
Trial end date:
2015-04-01
Target enrollment:
Participant gender:
Summary
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor
cells, either by killing the cells or by stopping them from dividing. Giving more than one
drug (combination chemotherapy) may kill more tumor cells. Metformin hydrochloride may stop
the growth of tumor cells by blocking some of the enzymes needed for cell growth. It is not
yet known if combination chemotherapy is more effective with or without metformin
hydrochloride in treating patients with metastatic pancreatic cancer.
PURPOSE: This randomized phase II trial is studying giving cisplatin, epirubicin
hydrochloride, capecitabine, and gemcitabine hydrochloride together with metformin
hydrochloride to see how well it works compared to cisplatin, epirubicin hydrochloride,
capecitabine, and gemcitabine hydrochloride alone in treating patients with metastatic
pancreatic cancer.