Overview

Combination Chemotherapy With or Without Bone Marrow Transplantation in Treating Children With Acute Myeloid Leukemia

Status:
Completed
Trial end date:
2005-12-01
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with bone marrow transplantation may allow doctors to give higher doses of chemotherapy and kill more cancer cells. It is not yet known whether chemotherapy is more effective with or without bone marrow transplantation for acute myeloid leukemia. PURPOSE: Randomized phase III trial to compare the effectiveness of chemotherapy with or without bone marrow transplantation in treating children who have acute myeloid leukemia.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Medical Research Council
Treatments:
Amsacrine
Asparaginase
Cortisol succinate
Cytarabine
Daunorubicin
Etoposide
Hydrocortisone
Hydrocortisone 17-butyrate 21-propionate
Hydrocortisone acetate
Hydrocortisone hemisuccinate
Methotrexate
Mitoxantrone
Criteria
DISEASE CHARACTERISTICS:

- One of the following diagnoses:

- Histologically confirmed de novo or secondary acute myeloid leukemia (AML)

- Aggressive myelodysplastic syndromes (refractory anemia with excess blasts (RAEB)
and RAEB in transformation) for which intensive AML therapy is considered
appropriate

- Acute promyelocytic leukemia (should also be entered into protocol MRC-ATRA)

- No chronic myeloid leukemia in blast transformation

- Must be considered suitable for intensive chemotherapy

PATIENT CHARACTERISTICS:

Age:

- Under 16

Performance status:

- Not specified

Life expectancy:

- Not specified

Hematopoietic:

- Not specified

Hepatic:

- Not specified

Renal:

- Not specified

Other:

- No other concurrent active malignancy

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- Not specified

Chemotherapy:

- No prior chemotherapy for leukemia

Endocrine therapy:

- Not specified

Radiotherapy:

- Not specified

Surgery:

- Not specified