Overview

Combination Chemotherapy, Surgery, and Radiation Therapy in Treating Children With Advanced Soft Tissue Sarcoma

Status:
Completed
Trial end date:
2006-04-01
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one chemotherapy drug with radiation therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy, surgery, and radiation therapy in treating children who have advanced soft tissue sarcoma.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Children's Oncology Group
Collaborator:
National Cancer Institute (NCI)
Treatments:
Cobalt
Doxorubicin
Ifosfamide
Isophosphamide mustard
Lenograstim
Liposomal doxorubicin
Mesna
Sargramostim
Vincristine
Criteria
DISEASE CHARACTERISTICS: Biopsy proven non-rhabdomyosarcoma soft tissue sarcoma (NRSTS)
Evaluable residual tumor after initial biopsy or excision required Registration required
within 42 days of definitive diagnosis Grade II/III, unresectable or metastatic disease The
following histologies exclude: Angiofibroma of the nasopharynx Mesothelioma Desmoid tumor
Peripheral neuroepithelioma Desmoplastic small cell tumor Rhabdomyosarcoma Extraosseous
Ewing's sarcoma Undifferentiated sarcoma Kaposi's sarcoma Grade 1 NRSTS, including:
Angiomatoid malignant fibrous histiocytoma Dermatofibrosarcoma protuberans Myxoid and
well-differentiated liposarcoma Well-differentiated and infantile hemangiopericytoma
Well-differentiated malignant peripheral nerve sheath tumor

PATIENT CHARACTERISTICS: Age: 21 and under Performance status: Not specified Hematopoietic:
Not specified Hepatic: Not specified Renal: Creatinine normal for age No hydronephrosis
Cardiovascular: Shortening fraction greater than 28% Other: No HIV infection Not pregnant
or nursing Effective contraception required of fertile women

PRIOR CONCURRENT THERAPY: No prior chemotherapy or radiotherapy No prior nephrectomy
(surgical correction of hydronephrosis allowed)