Overview

Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer

Status:
Terminated
Trial end date:
2002-03-01
Target enrollment:
0
Participant gender:
All
Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining chemotherapy and radiation therapy may kill more tumor cells. PURPOSE: Phase I/II trial to study the effectiveness of combination chemotherapy plus radiation therapy in treating patients who have stage III non-small cell lung cancer.
Phase:
Phase 1/Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Northwestern University
Collaborator:
National Cancer Institute (NCI)
Treatments:
Albumin-Bound Paclitaxel
Carboplatin
Gemcitabine
Paclitaxel
Vinblastine
Vinorelbine
Criteria
DISEASE CHARACTERISTICS: Histologically or cytologically confirmed stage IIIA or IIIB
non-small cell lung cancer Pathologic staging of mediastinal lymph nodes required (N2, N3)
Bidimensionally measurable disease by x-ray, CT scan, or MRI OR Evaluable disease (e.g.,
pulmonary infiltrate evaluable on x-ray) No malignant pleural effusions

PATIENT CHARACTERISTICS: Age: 18 and over Performance status: ECOG 0-2 Life expectancy: At
least 8 weeks Hematopoietic: Absolute neutrophil count at least 1,500/mm3 Platelet count at
least 100,000/mm3 Hepatic: Bilirubin no greater than 1.5 times upper limit of normal (ULN)
SGOT no greater than 3 times ULN Renal: Creatinine no greater than 1.5 times ULN OR
Creatinine clearance at least 50 mL/min Cardiovascular: No active cardiac ischemia No
congestive heart failure Other: No significant active infection No other severe
complicating medical illness (e.g., severe neurologic or psychiatric disease that would
prevent compliance) No concurrent malignancy except nonmelanoma skin cancer or carcinoma in
situ of the cervix Not pregnant or nursing Fertile patients must use effective
contraception

PRIOR CONCURRENT THERAPY: Biologic therapy: Not specified Chemotherapy: No prior
chemotherapy Endocrine therapy: Not specified Radiotherapy: No prior pelvic or thoracic
radiotherapy Surgery: Not specified