Combination Chemotherapy, Peripheral Stem Cell Transplantation, and Biological Therapy in Treating Patients With Solid Tumors or Lymphoma

• Status: Completed
• Trial end date: 2007-11-01
• Target enrollment: 0
• Participant gender: All

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. Biological therapies such as interleukin-2 use different ways to stimulate the immune system and stop cancer cells from growing.

PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy, peripheral stem cell transplantation, and interleukin-2 in treating patients who have solid tumors or lymphoma.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Fred Hutchinson Cancer Research Center
• Collaborator: National Cancer Institute (NCI)
• Treatments: Aldesleukin; Busulfan; Cyclophosphamide; Melphalan; Paclitaxel; Sargramostim; Thiotepa

Criteria

DISEASE CHARACTERISTICS:

• Diagnosis of solid tumor, Hodgkin's lymphoma, or B-cell non-Hodgkin's lymphoma

• Eligible for autologous stem cell transplantation

• No pleural effusion, pericardial effusion, or ascites

• No T-cell lymphoma

PATIENT CHARACTERISTICS:

Age:

• Under 57

Performance status:

• Karnofsky 80-100%

Life expectancy:

• Not specified

Hematopoietic:

• Not specified

Hepatic:

• Bilirubin no greater than 1.5 mg/dL (unless due to Gilbert's disease)

• SGOT or SGPT no greater than 2 times upper limit of normal

• Hepatitis B and C negative

Renal:

• Creatinine no greater than 2.0 mg/dL OR

• Creatinine clearance at least 60 mL/min

Cardiovascular:

• LVEF at least 50%

• No congestive heart disease

• No history of myocardial infarction within the past year

• No coronary artery disease

• No history of arrhythmia

Pulmonary:

• Diffusion capacity (corrected) at least 60%

• FEV_1 at least 65% of predicted

Other:

• HIV negative

• No history of seizures

• No mental disorders requiring medication (e.g., haloperidol)

• No active connective tissue disease

• No other malignancy within the past 5 years except basal cell or squamous cell skin cancer or any carcinoma in situ

• No allergy to gentamicin

• No hypersensitivity to E. coli-derived preparations

• No history of severe allergy to sargramostim (GM-CSF) or filgrastim (G-CSF)

• No systemic infection

• Not pregnant

PRIOR CONCURRENT THERAPY:

Biologic therapy:

• See Disease Characteristics

Chemotherapy:

• Not specified

Endocrine therapy:

• No concurrent corticosteroid therapy

Radiotherapy:

• Not specified

Surgery:

• Not specified

Other:

• No contrast dye for 3 weeks after completion of interleukin-2 therapy