Overview

Combination Chemotherapy Given With Radiation Therapy or Radiation Therapy Alone in Treating Patients With Early-Stage Hodgkin's Disease

Status:
Unknown status

Trial end date:
1969-12-31

Target enrollment:
0

Participant gender:
All

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining radiation therapy with chemotherapy may kill more tumor cells. PURPOSE: Randomized phase III trial to compare the effectiveness of combination chemotherapy plus radiation therapy with radiation therapy alone in treating patients with early-stage Hodgkin's disease.

Phase:

Phase 3

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Medical Research Council

Treatments:

Bleomycin
Cyclophosphamide
Doxorubicin
Etoposide
Liposomal doxorubicin
Prednisolone
Vincristine

Criteria

DISEASE CHARACTERISTICS: Histologically proven stage IA or IIA Hodgkin's disease without
mediastinal bulk Patients with Hodgkin's disease existing below diaphragm only are not
eligible

PATIENT CHARACTERISTICS: Age: 16 to 75 Performance status: Not specified Life expectancy:
Not specified Hematopoietic: Not specified Hepatic: Not specified Renal: Not specified
Other: Not HIV positive No prior malignancy other than basal cell carcinoma or cervical
intraepithelial neoplasia

PRIOR CONCURRENT THERAPY: No prior treatment